![]() Oral Suspension “Instructions for Use” for complete instruction on how to properly dose and administer the Clion The cap fits over the adapter when the adapter is properly placed. ![]() Oral Suspension into the corner of the patient’s mouth. After removing the syringe from the bottle adapter, slowly squirt Clion ![]() To withdraw the dose, insert the dosing syringe into the adapter and invert the bottle then slowly pull back the plunger to prescribed dose. Insert the provided adapter firmly into the neck of the bottle before first use and keep the adapter in place for the duration of the usage of the bottle. The second oral syringe is reserved as a replacement in case the first syringe is damaged or lost. Each carton includes two syringes, but only one syringe should be used for dosing. When administering the oral suspension, use only the oral dosing syringe provided with the product. Oral Suspension well before every administration. Oral Suspension can be taken with or without food. Instruct patients to read the “Instructions for Use” carefully for complete directions on how to properly dose and administer Clion Taper by decreasing the total daily dose by 5 to 10 mg/day on a weekly basis until discontinued. Recommended Total Daily Dosing by Weight GroupĪs with all antiepileptic drugs and benzodiazepines, withdraw Clion Do not proceed with dose escalation more rapidly than weekly, because serum concentrations of Clion and its active metabolite require 5 and 9 days, respectively, to reach steady-state. Each dose in Table 1 (e.g., 5 to 20 mg in ≤30 kg weight group) has been shown to be effective, although effectiveness increases with increasing dose. Individualize dosing within each body weight group, based on clinical efficacy and tolerability. Oral Suspension greater than 5 mg should be administered in divided doses twice daily a 5 mg daily dose can be administered as a single dose. An oral suspension is expected to be available in 2013. The oral preparation was FDA approved on October 21, 2011. It has been marketed as an anxiolytic since 1975 and an anticonvulsant since 1984. Lennox-Gastaut syndrome: Adjunctive treatment of seizures associated with Lennox-Gastaut syndrome in patients ≥2 yearsĭata from a limited number of patients studied suggest that Clion may be beneficial for the treatment of catamenial epilepsy.īased on the American Academy of Neurology and the American Epilepsy Society practice guideline update summary on the efficacy and tolerability of the new antiepileptic drugs II: treatment-resistant epilepsy, Clion is possibly effective as add-on therapy for treatment-resistant adult focal epilepsy.Ĭlion belongs to the 1,5-benzodiazepine class of drugs and is expected to have a better side-effect profile compared to older 1,4-benzodiazepines. Do not take 2 doses at once.Īsk your health care provider any questions you may have about how to use Clion suspension. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. If you miss a dose of Clion suspension, take it as soon as possible.Replace the cap on Clion suspension after each use.Ask your pharmacist for help if you are unsure of how to measure your dose. Use the measuring device that comes with Clion suspension to measure your dose.Take Clion suspension by mouth with or without food.Read it again each time you get Clion suspension refilled. Clion suspension comes with an extra patient information sheet called a Medication Guide.Check the label on the medicine for exact dosing instructions. Use Clion suspension as directed by your doctor. Oral Suspension is indicated for the adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in patients 2 years of age or older.
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